Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors
CM Abuhaie, A Ghinet, A Farce, J Dubois… - European Journal of …, 2013 - Elsevier
Two new families of human farnesyltransferase inhibitors 13a–m and 14a–d, based on a
phenothiazine scaffold, were synthesized. Compounds 14a and 14b were the most
promising inhibitors of human farnesyltransferase with IC50 values of 0.7 and 0.6 μM,
respectively.
phenothiazine scaffold, were synthesized. Compounds 14a and 14b were the most
promising inhibitors of human farnesyltransferase with IC50 values of 0.7 and 0.6 μM,
respectively.
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